Optical and non‐optical methods for detection and characterization of microparticles and exosomes

  title={Optical and non‐optical methods for detection and characterization of microparticles and exosomes},
  author={E. van der Pol and Alfons G. Hoekstra and A. Sturk and C. Otto and T. V. van Leeuwen and R. Nieuwland},
  journal={Journal of Thrombosis and Haemostasis},
  • E. van der Pol, Alfons G. Hoekstra, +3 authors R. Nieuwland
  • Published 2010
  • Biology, Medicine
  • Journal of Thrombosis and Haemostasis
  • Summary.  Microparticles and exosomes are cell‐derived microvesicles present in body fluids that play a role in coagulation, inflammation, cellular homeostasis and survival, intercellular communication, and transport. Despite increasing scientific and clinical interest, no standard procedures are available for the isolation, detection and characterization of microparticles and exosomes, because their size is below the reach of conventional detection methods. Our objective is to give an overview… CONTINUE READING
    389 Citations

    Topics from this paper

    Innovation in detection of microparticles and exosomes
    • 190
    • PDF
    Methods for the physical characterization and quantification of extracellular vesicles in biological samples.
    • 75
    Analytical challenges of extracellular vesicle detection: A comparison of different techniques
    • 132
    Exosomes and Microvesicles: Identification and Targeting By Particle Size and Lipid Chemical Probes
    • 103
    Light-scattering flow cytometry for identification and characterization of blood microparticles.
    • 38
    • PDF


    Measuring circulating cell‐derived microparticles
    • 438
    Cell‐derived microparticles contain caspase 3 in vitro and in vivo
    • 77
    Cellular microparticles: what are they bad or good for?
    • J. Freyssinet
    • Biology, Medicine
    • Journal of thrombosis and haemostasis : JTH
    • 2003
    • 415
    Human cell‐derived microparticles promote thrombus formation in vivo in a tissue factor‐dependent manner
    • 263
    • PDF