Optical analysis of the HIF-1 complex in living cells by FRET and FRAP.

Abstract

Hypoxia-inducible factor-1 (HIF-1) coordinates the cellular response to a lack of oxygen by controlling the expression of hypoxia-inducible genes that ensure an adequate energy supply. Assembly of the HIF-1 complex by its oxygen-regulated subunit HIF-1alpha and its constitutive beta subunit also known as ARNT is the key event of the cellular genetic… (More)

Topics

Cite this paper

@article{Wotzlaw2007OpticalAO, title={Optical analysis of the HIF-1 complex in living cells by FRET and FRAP.}, author={Christoph Wotzlaw and Teresa Otto and Utta Berchner-Pfannschmidt and Eric Metzen and Helmut Acker and Joachim Fandrey}, journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, year={2007}, volume={21 3}, pages={700-7} }