Optical Control of Mammalian Endogenous Transcription and Epigenetic States

  title={Optical Control of Mammalian Endogenous Transcription and Epigenetic States},
  author={Silvana Konermann and Mark D. Brigham and Alexandro E. Trevino and Patrick D. Hsu and Matthias Heidenreich and Le Chi Cong and Randall J Platt and David Allen Scott and George M Church and Feng Zhang},
The dynamic nature of gene expression enables cellular programming, homeostasis and environmental adaptation in living systems. Dissection of causal gene functions in cellular and organismal processes therefore necessitates approaches that enable spatially and temporally precise modulation of gene expression. Recently, a variety of microbial and plant-derived light-sensitive proteins have been engineered as optogenetic actuators, enabling high-precision spatiotemporal control of many cellular… CONTINUE READING
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