Optic neuritis

@article{Rodrguez1995OpticN,
  title={Optic neuritis},
  author={M. Rodr{\'i}guez and Axel Siva and Shelley Ann Cross and Peter C O'brien and Leonard T. Kurland},
  journal={Neurology},
  year={1995},
  volume={45},
  pages={244 - 250}
}
Article abstract—We reviewed the records of all patients with optic neuritis (ON) in Olmsted County, Minnesota, identified through the comprehensive records-linkage system at the Mayo Clinic, and identified 156 ON patients from 1935 to 1991 who had onset of the disease while residing in Olmsted County (incidence cases). Poisson regression analysis revealed that age, gender, and calendar year were associated with incidence. The annual age- and sex-adjusted incidence rate was 5.1 per 100,000… 
Risk factors for developing multiple sclerosis after childhood optic neuritis
TLDR
This study of childhood ON supports the lower risk of recurrence and progression to MS compared with adults, and the presence of bilateral sequential or recurrent ON increased the risk of developing MS.
Trends in Optic Neuritis Incidence and Prevalence in the UK and Association With Systemic and Neurologic Disease.
TLDR
The highest risk of incident Optic neuritis was associated with female sex, obesity, reproductive age, smoking, and residence at higher latitude, with significantly lower risk in South Asian or mixed race/ethnicity compared with White people.
Incidence of optic neuritis in Stockholm, Sweden 1990–1995: I. Age, sex, birth and ethnic-group related patterns
TLDR
It is shown that monosymptomatic optic neuritis occurred in Stockholm at a relatively low frequency, particularly among males, and the presence of particular birth date and birth place related patterns might be etiologically relevant.
A nine-year population-based cohort study on the risk of multiple sclerosis in patients with optic neuritis.
TLDR
This study found that Taiwanese patients with ON are at a substantially high relative risk of developing MS, and female and younger people should also receive intensive neurological care to further reduce their risk of developed MS.
Is the incidence of optic neuritis rising? Evidence from an epidemiological study in Barcelona (Spain), 2008–2012
TLDR
The incidence of optic neuritis in Barcelona during 2008–2012 was higher than previously reported and may reflect the evolution of diagnostic criteria, the use of a referral-center approach instead of a population-based approach, increased awareness of demyelinating diseases, latitude-related factors and possibly a true increase in its incidence.
Assessment of Outcome Predictors after First Attack of Optic Neuritis
Background: Optic Neuritis (ON) is one of the most common clinically isolated syndromes which develops into clinically diagnosed Multiple Sclerosis (CDMS) over time. Objective: To assess the
Risk of Multiple Sclerosis after Idiopathic Optic Neuritis in a Pakistani Population
TLDR
Iiopathic ON in Pakistan carries a lower risk of progression to MS compared with Western data, however, presence of abnormal baseline brain MRI and CSF oligoclonal bands correlate with increased MS risk.
Incidence of optic neuritis in Stockholm, Sweden, 1990-1995: II. Time and space patterns.
TLDR
Environmental and probable infectious factors unevenly distributed by season may play a role in the etiology and early clinical course of monosymptomatic optic neuritis in Stockholm County, Sweden.
Incidence and Mimickers of Acute Idiopathic Optic Neuritis: Analysis of 291 Consecutive Patients from Southern Finland
TLDR
The use of MRI is recommended to improve the differential diagnostic accuracy of ON and to identify patients with high risk of MS, as demyelinative lesions on MRI indicated higher risk of developing MS.
Pediatric optic neuritis.
TLDR
Pediatric optic neuritis has no gender or racial predilection, is usually bilateral, and is associated with ADEM rather than MS.
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References

SHOWING 1-10 OF 46 REFERENCES
THE EPIDEMIOLOGY OF OPTIC NEURITIS IN FINLAND
TLDR
The epidemiological data point to a common factor in the aetiology of optic neuritis and MS, which is likely to depend on the influence of factors present during childhood.
A reappraisal of the epidemiology of multiple sclerosis in Olmsted County, Minnesota
A review of multiple sclerosis (MS) case reports, using the unified record system at the Mayo Clinic for the Olmsted County population, revealed age- and sex-adjusted prevalence rates per 100,000
A long‐term prospective study of optic neuritis: Evaluation of risk factors
TLDR
Female gender, onset in the winter season, and the presence of HLA‐DR2 antigen increased the risk for MS, but not significantly, and normal CSF at the onset of optic neuritis conferred better prognosis but did not preclude the development of MS.
Optic neuritis as an initial symptom in multiple sclerosis
TLDR
The findings do not support the idea of initial ON as being a favorable sign of the later course, but the frequency of brainstem/cerebellar and pyramidal signs was lowest among these patients at the time of the present examination.
OPTIC NEURITIS—A SIGN OF MULTIPLE SCLEROSIS OR OTHER DISEASES OF THE CENTRAL NERVOUS SYSTEM
A neurological and ophthalmological re‐examination has been carried out of 116 patients with optic neuritis (ON), who were treated at the eye clinic of the Central Hospital of Turku University during
A reassessment of the risk of multiple sclerosis developing in patients with optic neuritis after extended follow-up.
TLDR
Recurrent episodes of optic neuritis were associated with an increased risk for the development of multiple sclerosis in this study and the overall increased risk of developing multiple sclerosis for patients with this combination was 26 times that for the normal population.
Acute optic neuritis: a prospective study of risk factors for multiple sclerosis.
TLDR
The frequency of HLA-DR4 was increased in patients with optic neuritis alone compared to controls and to patients with multiple sclerosis, but further studies are required to confirm this finding.
A prospective study of the risk of developing multiple sclerosis in uncomplicated optic neuritis
TLDR
There was an overall increased risk of MS with recurrent ON and both sexes were at highest risk if the ON occurred between the ages of 21 and 40.
Bilateral optic neuritis. A long-term follow-up.
TLDR
It is concluded that the risk of developing multiple sclerosis after simultaneous bilateral optic neurities in childhood is low; in adult life it is probably higher, but some patients even after more than two decades have no clinical evidence of the disseminated disease.
STUDIES ON THE NATURAL HISTORY OF MULTIPLE SCLEROSIS
TLDR
Early in the investigation, however, it became clear that the great majority of men with optic neuritis were not considered to have multiple sclerosis according to subsequent Veterans Administration records, and the study was redirected to the question of the likelihood of multiple sclerosis developing after an attack of optics neuritis in young adult males.
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