Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity.

@article{Bajenaru2003OpticNG,
  title={Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity.},
  author={Michaela Livia Bajenaru and M. Rosario Hernandez and Arie Perry and Yuan Zhu and Luis F. Parada and Joel R. Garbow and David H Gutmann},
  journal={Cancer research},
  year={2003},
  volume={63 24},
  pages={8573-7}
}
Whereas biallelic neurofibromatosis 1 (NF1) inactivation is observed in NF1-associated gliomas, astrocyte-restricted Nf1 conditional knockout mice do not develop gliomas. These observations suggest that NF1 glioma formation requires additional cellular or genetic conditions. To determine the effect of an Nf1 heterozygous brain environment on NF1 glioma formation, we generated Nf1+/- mice lacking Nf1 expression in astrocytes. In contrast to astrocyte-restricted Nf1 conditional knockout mice, Nf1… CONTINUE READING
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