Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic glioma.

Abstract

Individuals with neurofibromatosis type 1 (NF1) are prone to develop optic pathway gliomas that can result in significant visual impairment. To explore the cellular basis for the reduced visual function resulting from optic glioma formation, we used a genetically engineered mouse model of Nf1 optic glioma (Nf1+/-(GFAP)CKO mice). We performed multimodal… (More)
DOI: 10.1097/NEN.0b013e3181a3240b

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