Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic

@article{Ahmed2010OpticNA,
  title={Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic},
  author={Zubair Ahmed and Mudasser Aslam and Barbara Lorber and Ellen L. Suggate and Ann Logan},
  journal={Neurobiology of Disease},
  year={2010},
  volume={37},
  pages={441-454}
}
Intravitreal inflammation, induced by either lens injury, or intravitreal injection of zymosan (IVZ), protects RGC from apoptosis and stimulates axon regeneration after optic nerve transection. Here, we investigate the differential effects of intra-optic nerve zymosan (ONZ) and IVZ injections on RGC neuroprotection and axogenesis. After both IVZ and ONZ injection, zymosan-induced inflammation promoted a similar 4-/5-fold enhancement in RGC survival, compared to optic nerve transected controls… CONTINUE READING
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