Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury.

@article{Ishida2006OppositeRO,
  title={Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury.},
  author={Yuko Ishida and Toshikazu Kondo and Akihiko Kimura and Kouichi Tsuneyama and Tatsunori Takayasu and Naofumi Mukaida},
  journal={European journal of immunology},
  year={2006},
  volume={36 4},
  pages={1028-38}
}
Neutrophils and macrophages infiltrate after acetaminophen (APAP)-induced liver injury starts to develop. However, their precise roles still remain elusive. In untreated and control IgG-treated wild-type (WT) mice, intraperitoneal APAP administration (750 mg/kg) caused liver injury including centrilobular hepatic necrosis and infiltration of neutrophils and macrophages, with about 50% mortality within 48 h after the injection. APAP injection markedly augmented intrahepatic gene expression of… CONTINUE READING

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