Opposite role for interleukin‐4 and interferon‐γ on CD30 and lymphocyte activation gene‐3 (LAG‐3) expression by activated naive T cells

@article{Annunziato1997OppositeRF,
  title={Opposite role for interleukin‐4 and interferon‐$\gamma$ on CD30 and lymphocyte activation gene‐3 (LAG‐3) expression by activated naive T cells},
  author={Francesco Annunziato and Roberto Manetti and Lorenzo Cosmi and Grazia Galli and Christoph H. Heusser and Sergio Romagnani and Enrico Maggi},
  journal={European Journal of Immunology},
  year={1997},
  volume={27}
}
Polarized human type 1 and type 2 T helper cells not only produce different sets of cytokines, but they also preferentially express certain activation markers, such as lymphocyte activation gene‐3 (LAG‐3) and CD30, respectively. In this study we have examined the LAG‐3 and CD30 expression in relation to the lineage commitment of human naive CD4+ T cells, as assessed at the single‐cell level of committed T cells. Purified CD45RA+ umbilical cord blood T lymphocytes were activated with… Expand
Lymphocyte activation gene-3 (LAG-3) expression and IFN-gamma production are variably coregulated in different human T lymphocyte subpopulations.
TLDR
The data do not support the earlier suggestion that LAG-3 and CD30 are selective markers of T cells with type-1 and type-2 cytokine profiles, respectively. Expand
Segregation of Effector Mechanisms in a Tumour‐Specific CD8+ T‐Cell Clone Correlates with CD30 Expression
TLDR
The results suggest that CD30 antigen can be inducible on a subset of tumour‐directed CD8+ CTL, and that this subset of cells may have profound effector functions, such as cytokine secretion, proliferation, and cytotoxicity. Expand
Progressive polarization towards a T helper/cytotoxic type‐1 cytokine pattern during age‐dependent maturation of the immune response inversely correlates with CD30 cell expression and serum concentration
TLDR
The results showed a progressive increase of circulating Th(c)1‐type, interferon‐gamma (IFN‐γ)‐ and/or IL‐2‐producing T cells along with ageing and, conversely, a stable number, although higher than in cord blood samples, of CD4+/IL‐4+ T cells in the post‐natal groups. Expand
Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II
Abstract The lymphocyte activation gene-3 (LAG-3), a major histocompatibility complex (MHC) class II ligand evolutionarily related to CD4, is expressed exclusively in activated T and NK lymphocytesExpand
Enhanced HIV expression during Th2‐oriented responses explained by the opposite regulatory effect of IL‐4 and IFN‐γ on fusin/CXCR4
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The down‐regulatory effect of IL‐12 on CXCR4 expression was found to be dependent on its capacity to induce IFN‐γ production, which can account for the higher risk of progression in HIV‐1‐infected individuals undergoing Th0/2‐oriented immune responses. Expand
CD30 Expression Identifies the Predominant Proliferating T Lymphocyte Population in Human Alloimmune Responses1
TLDR
It is observed that allogeneic APC consistently induced a greater proportion of CD30+ cells within the activated T cell population than did stimulation with plate-bound anti-CD3 plusAnti-CD28 mAb or stimulation with soluble anti- CD3 plus anti-cd28 and autologous APC. Expand
Altered Th1/Th2 commitment in human CD4+ T cells with ageing
TLDR
The results together suggest that the microenvironment in which CD4+ T cells develop in older people may cause production of more cells committed to Th1 than that in younger subjects. Expand
Lymphocyte activation gene-3 : the expression and function in the immune system
TLDR
The main finding of this work is that, unlike previously thought, LAG-3 expression is not only limited to activated T and NK cells, but can also be induced on B cells and DCs, which suggests a novel co-stimulatory function of L AG-3 on APCs. Expand
Lymphotoxin alphabeta is expressed on recently activated naive and Th1-like CD4 cells but is down-regulated by IL-4 during Th2 differentiation.
TLDR
It is demonstrated that LTalphabeta is expressed by activated naive CD4 cells, unpolarized IL-2-secreting effectors, and Th1 effectors and loss of surface LT Ralphabeta and a lack of LTalpha3 and TNF secretion is associated with prior exposure to IL-4 and a Th2 phenotype. Expand
Regulation of CD30 antigen expression and its potential significance for human disease.
  • M. Kadin
  • Biology, Medicine
  • The American journal of pathology
  • 2000
TLDR
CD30 antigen, a member of the tumor necrosis factor (TNF) receptor superfamily, was originally identified as a cell surface antigen on primary and cultured Hodgkin’s and Reed-Sternberg cells by use of the monoclonal antibody Ki-1 and has been detected on a subset of tissue and circulating CD4+ and CD8+ T cells producing mainly Th2 cytokines in immunoreactive conditions. Expand
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