Opposite risk patterns for autism and schizophrenia are associated with normal variation in birth size: phenotypic support for hypothesized diametric gene-dosage effects.

@article{Byars2014OppositeRP,
  title={Opposite risk patterns for autism and schizophrenia are associated with normal variation in birth size: phenotypic support for hypothesized diametric gene-dosage effects.},
  author={Sean Geoffrey Byars and Stephen C Stearns and Jacobus J Boomsma},
  journal={Proceedings. Biological sciences},
  year={2014},
  volume={281 1794},
  pages={20140604}
}
Opposite phenotypic and behavioural traits associated with copy number variation and disruptions to imprinted genes with parent-of-origin effects have led to the hypothesis that autism and schizophrenia share molecular risk factors and pathogenic mechanisms, but a direct phenotypic comparison of how their risks covary has not been attempted. Here, we use health registry data collected on Denmark's roughly 5 million residents between 1978 and 2009 to detect opposing risks of autism and… CONTINUE READING
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