Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes.

@article{Berger2012OppositeRO,
  title={Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes.},
  author={Julie V Berger and Am{\'e}lie O. Dumont and Maryl{\`e}ne C Focant and Maxime Vergouts and Anthony Sternotte and A-G Calas and St{\'e}phanie Goursaud and Emmanuel Hermans},
  journal={Neuroscience},
  year={2012},
  volume={205},
  pages={29-38}
}
Metabotropic glutamate receptors (mGluRs) were previously shown to modulate several essential functions in glial cells, including cell proliferation, glutamate uptake, neurotrophic support, and inflammatory responses. As these receptors are regularly proposed as promising targets for the treatment of a wide range of neurological disorders, we herein examined the reciprocal modulation of glial mGluRs by inflammation. Such regulation of mGluRs was also studied in cultures from an experimental… CONTINUE READING
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