Opposite regulation of epithelial-to-mesenchymal transition and cell invasiveness by periostin between prostate and bladder cancer cells.

@article{Kim2011OppositeRO,
  title={Opposite regulation of epithelial-to-mesenchymal transition and cell invasiveness by periostin between prostate and bladder cancer cells.},
  author={Chul Jang Kim and Kanami Sakamoto and Yukihiro Tambe and Hirokazu Inoue},
  journal={International journal of oncology},
  year={2011},
  volume={38 6},
  pages={
          1759-66
        }
}
We previously showed that periostin expression is downregulated in human bladder cancer tissues and that ectopic expression of periostin suppresses the invasiveness of bladder cancer cells. However, in most other human cancers studied, the expression of periostin promotes cell invasiveness. In the present study, we investigated the regulation of the epithelial-to-mesenchymal transition (EMT) and cell invasiveness by periostin in bladder and prostate cancer cell lines, and found opposite… CONTINUE READING
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