Opposite regulation of KCNQ5 and TRPC6 channels contributes to vasopressin-stimulated calcium spiking responses in A7r5 vascular smooth muscle cells.

@article{Mani2009OppositeRO,
  title={Opposite regulation of KCNQ5 and TRPC6 channels contributes to vasopressin-stimulated calcium spiking responses in A7r5 vascular smooth muscle cells.},
  author={Bharath Kumar Mani and Lioubov I. Brueggemann and Leanne L. Cribbs and Kenneth L Byron},
  journal={Cell calcium},
  year={2009},
  volume={45 4},
  pages={400-11}
}
Physiologically relevant concentrations of [Arg(8)]-vasopressin (AVP) induce repetitive action potential firing and Ca(2+) spiking responses in the A7r5 rat aortic smooth muscle cell line. These responses may be triggered by suppression of KCNQ potassium currents and/or activation of non-selective cation currents. Here we examine the relative contributions of KCNQ5 channels and TRPC6 non-selective cation channels to AVP-stimulated Ca(2+) spiking using patch clamp electrophysiology and fura-2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Effects of siRNA knock - down of TRPC 6 and InsP ( 3 ) R 1 in vasopressin - induced Ca ( 2 + ) oscillations of A 7 r 5 vascular smooth muscle cells

  • R. R. Boyles, S. Y. Hwang, G. S. Bird, J. W. Putney
  • Pharmacol . Res .
  • 2008

Similar Papers

Loading similar papers…