Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum.

@article{Pozzi2003OppositeRB,
  title={Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum.},
  author={Laura Pozzi and Kerstin H{\aa}kansson and Alessandro Usiello and Anders Borgkvist and Maria Lindskog and Paul Greengard and Gilberto Fisone},
  journal={Journal of neurochemistry},
  year={2003},
  volume={86 2},
  pages={451-9}
}
The two mitogen-activated protein kinases (MAPKs), extracellular signal-regulated protein kinase 1 and 2 (ERK1/2), are involved in the control of gene expression via phosphorylation and activation of the transcription factors cyclic AMP response element binding protein (CREB) and Elk-1. Here, we have examined the effect of haloperidol and clozapine, two anti-psychotic drugs, and eticlopride, a selective dopamine D2 receptor antagonist, on the state of phosphorylation of ERK1/2, CREB and Elk-1… CONTINUE READING

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