Opposite motor effects of pallidal stimulation in Parkinson's disease.

  title={Opposite motor effects of pallidal stimulation in Parkinson's disease.},
  author={Paul Krack and Pierre Pollak and Patricia Limousin and Dominique Hoffmann and Abdelhamid Benazzouz and Jean François Le Bas and Adnan Koudsi{\'e} and A. L. Benabid},
  journal={Annals of neurology},
  volume={43 2},
We studied the effects--on parkinsonian signs, on levodopa-induced dyskinesias, and on levodopa response--of acute experimental high-frequency stimulation of the internal pallidum (GPi) during off-drug and on-drug phases. Thirteen quadripolar electrodes were evaluated in 8 patients with Parkinson's disease (PD). Stimulation of the most ventral contacts, lying at the ventral margin of or just below the GPi, led to pronounced improvement in rigidity and a complete arrest of levodopa-induced… CONTINUE READING
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