Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposure.

@article{Quarta2004OppositeMR,
  title={Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposure.},
  author={Davide Quarta and Sergi Ferr{\'e} and Marcello Solinas and Zhi-Bing You and J{\"o}rg Hockemeyer and Patrizia Popoli and Steven R. Goldberg},
  journal={Journal of neurochemistry},
  year={2004},
  volume={88 5},
  pages={1151-8}
}
Previous studies have demonstrated opposing roles for adenosine A1 and A2A receptors in the modulation of extracellular levels of glutamate and dopamine in the striatum. In the present study, acute systemic administration of motor-activating doses of the A2A receptor antagonist MSX-3 significantly decreased extracellular levels of dopamine and glutamate in the shell of the rat nucleus accumbens (NAc) and counteracted both dopamine and glutamate release induced by systemic administration of… CONTINUE READING
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