Opposite modulation of ouabain cardiotoxicity by hexamethyleneamiloride and phenylephrine

Abstract

To see whether the Na/H antiporter plays a role in digitalis cardiotoxicity, we investigated the influence of modulators of Na/H exchange on the toxic effects of ouabain in isolated, paced (0.4 Hz) rat left atria. Ouabain (1 mmol/l) caused a transient positive inotropic effect followed by toxic events, including a complete loss of developed force and a… (More)
DOI: 10.1007/BF00169554

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