Opposite modulation of apomorphine- or amphetamine-induced stereotypy by antagonists of CCK receptors.

@article{Tieppo2000OppositeMO,
  title={Opposite modulation of apomorphine- or amphetamine-induced stereotypy by antagonists of CCK receptors.},
  author={Carla A Tieppo and Fl{\'a}vio Silva Ferreira and Alexandre S Sassatani and Luciano F Felicio and Antonia Gladys Nasello},
  journal={European journal of pharmacology},
  year={2000},
  volume={387 2},
  pages={189-96}
}
Stereotyped behavior is elicited by activation of dopaminergic systems with drugs such as apomorphine and amphetamine. In previous studies, we have reported that the sulfated cholecystokinin octapeptide (CCK-8) decreased apomorphine-induced stereotypy in animals with normal and supersensitive dopamine receptors. The aim of the present study was to evaluate the effects of CCK(1) and CCK(2) receptor antagonists on stereotyped behavior induced by apomorphine or amphetamine. Rats were pretreated… CONTINUE READING