Opposite modulation of NMDA receptors by lysophospholipids and arachidonic acid: common features with mechanosensitivity.


1. Two classes of amphiphilic compounds, lysophospholipids and arachidonic acid, have been suggested to produce opposite deformations of the lipid bilayer. We have found that their effects on N-methyl-D-aspartate (NMDA) responses are opposite, and resemble those of mechanical deformations of the plasma membrane. 2. Lysophospholipids inhibited NMDA responses… (More)