Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior.

@article{Shumake2003OppositeMC,
  title={Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior.},
  author={Jason D Shumake and Emmeline Edwards and F. Gonzalez-Lima},
  journal={Brain research},
  year={2003},
  volume={963 1-2},
  pages={274-81}
}
Congenitally helpless rats have been selectively bred to display an immediate helpless response to stress in order to model hereditary brain differences that contribute to depression vulnerability. Differences in regional brain metabolism between congenitally helpless and non-helpless rats were investigated using quantitative cytochrome oxidase histochemistry. The results indicated that congenitally helpless rats had 64-71% elevated metabolism in the habenula and a 25% elevation in the related… CONTINUE READING

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