Opposite influences of different adrenoceptors on baclofen-induced antinociception in mice.

@article{Sabetkasai1997OppositeIO,
  title={Opposite influences of different adrenoceptors on baclofen-induced antinociception in mice.},
  author={M. Sabetkasai and R Doost-Mohammady and Mohammad Reza Zarrindast},
  journal={Pharmacology & toxicology},
  year={1997},
  volume={80 1},
  pages={6-10}
}
In the present study, the effects of adrenoceptor agonists and antagonists on baclofen-induced antinociception was investigated. Intraperitoneal administration of different doses of baclofen (2.5, 5 and 10 mg/kg) induced antinociception in the tail-flick test. The response was dose-dependent. The alpha 2-adrenoceptor agonist, clonidine, increased, while the alpha 1-adrenoceptor agonist, phenylephrine, decreased the baclofen response. In reserpine-treated animals, alpha 2-adrenoceptor, clonidine… CONTINUE READING