Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions

@article{Chae2011OppositeFO,
  title={Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions},
  author={Kyung Sil Chae and Min Joung Kang and Ji Hyun Lee and Bongha Ryu and Min Goo Lee and Nir Her and Tae Kwun Ha and J Han and Yong Kee Kim and Sung Gil Chi},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={1213-1228}
}
Transforming growth factor (TGF)-β1 has biphasic functions in prostate tumorigenesis, having a growth-inhibitory effect in the early stages, but in the late stages promoting tumor angiogenesis and metastasis. We demonstrate here that tumor-producing TGF-β1 induces vascular endothelial growth factor (VEGF) in prostate cancer cells, and hypoxia-inducible factor (HIF)-1α and HIF-2α has opposite functions in TGF-β1 regulation of VEGF expression under non-hypoxic conditions. The promoter response of… CONTINUE READING

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