Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis.

@article{Engel2012OppositeEO,
  title={Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis.},
  author={Matthias Agop Engel and Mohammad Athar Khalil and Norbert Siklosi and Sonja M. Mueller-Tribbensee and Winfried L Neuhuber and Markus F Neurath and Christoph Becker and Peter W Reeh},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  year={2012},
  volume={44 1},
  pages={24-9}
}
BACKGROUND Extrinsic sensory neurons play a crucial role in aberrant immune responses in colitis. The activation of peptidergic sensory nerve fibres is accompanied by a release of the neuropeptides calcitonin gene-related peptide (CGRP) and substance P (SP). SP levels increase whilst CGRP levels decrease in colon specimens from patients with inflammatory… CONTINUE READING