Opposite effects of simvastatin on the bactericidal and inflammatory response of macrophages to opsonized S. aureus.

@article{Benati2010OppositeEO,
  title={Opposite effects of simvastatin on the bactericidal and inflammatory response of macrophages to opsonized S. aureus.},
  author={Daniela Benati and Micol Ferro and Maria Teresa Savino and Cristina Ulivieri and Ebe Schiavo and Annalisa Nuccitelli and Franco Laghi Pasini and Cosima Tatiana Baldari},
  journal={Journal of leukocyte biology},
  year={2010},
  volume={87 3},
  pages={433-42}
}
Besides lowering circulating cholesterol, statins act as immunomodulators. Although the effects of statins on lymphocyte activation and differentiation have been clearly defined, there is no consensus as to effects of these drugs on phagocytes. We have addressed the outcome of simvastatin treatment on the activation and effector function of human macrophages in the pathophysiologically relevant context of challenge with an opportunistic pathogen. We provide evidence that: simvastatin blocks the… CONTINUE READING

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