Opposite effects of mu and kappa opiates on the firing-rate of dopamine cells in the substantia nigra of the rat.

@article{Walker1987OppositeEO,
  title={Opposite effects of mu and kappa opiates on the firing-rate of dopamine cells in the substantia nigra of the rat.},
  author={Jennifer M. Walker and Laird A. Thompson and Joseph Frascella and M W Friederich},
  journal={European journal of pharmacology},
  year={1987},
  volume={134 1},
  pages={53-9}
}
Single unit extracellular recording was carried out in rats to compare the actions of a mu receptor agonist (morphine) to a kappa receptor agonist (U50,488) in the substantia nigra pars compacta (SNC). Intravenously administered morphine and U50,488 exhibited opposite effects: morphine excited SNC dopamine cells, and U50,488 inhibited them. Both effects were blocked by naloxone, although significantly more naloxone was necessary to block the effect of the kappa agonist. Local administration of… CONTINUE READING

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