Opposite effects of low and high doses of the gastrin-releasing peptide receptor antagonist RC-3095 on memory consolidation in the hippocampus: possible involvement of the GABAergic system.

@article{Dantas2006OppositeEO,
  title={Opposite effects of low and high doses of the gastrin-releasing peptide receptor antagonist RC-3095 on memory consolidation in the hippocampus: possible involvement of the GABAergic system.},
  author={Andrea dos Santos Dantas and Tatiana Luft and Jo{\~a}o Antonio P{\^e}gas Henriques and Gilberto Schwartsmann and Rafael Roesler},
  journal={Peptides},
  year={2006},
  volume={27 9},
  pages={2307-12}
}
Although the gastrin-releasing peptide receptor (GRPR) has recently emerged as a system importantly involved in regulating memory formation, the role of hippocampal GRPRs in memory remains controversial. The present study examined the effects of GRPR antagonism on memory consolidation in area CA1 of the hippocampus. Male Wistar rats received bilateral infusions of the GRPR antagonist [D-Tpi6, Leu13 psi(CH2NH)-Leu14] bombesin (6-14) (RC-3095; 1, 3, or 10 microg/side) into the dorsal hippocampus… CONTINUE READING

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