Opposite effects of diazepam and beta-CCE on immobility and straw-climbing behavior of rats in a modified forced-swim test.

@article{Nishimura1989OppositeEO,
  title={Opposite effects of diazepam and beta-CCE on immobility and straw-climbing behavior of rats in a modified forced-swim test.},
  author={Hayato Nishimura and Yoshiteru Ida and Akira Tsuda and Masatoshi Tanaka},
  journal={Pharmacology, biochemistry, and behavior},
  year={1989},
  volume={33 1},
  pages={227-31}
}
The present study was undertaken to examine how two ligands of the benzodiazepine receptor, which possess anxiolytic or anxiogenic actions, affect both the duration of immobility and the incidence of straw-climbing behavior in rats in a modified forced-swim test. Rats were injected IP with either vehicle, diazepam (0.5, 1, 5 mg/kg), or beta-carboline-3-carboxylic acid ethyl ester (beta-CCE; 0.5, 1, 2, 5 mg/kg), or a combination of diazepam at 1 mg/kg and beta-CCE at 2 mg/kg. In addition, Ro 15… CONTINUE READING