Opposite effects of diabetes on nephrotoxic and ischemic acute tubular necrosis.

@article{Wald1990OppositeEO,
  title={Opposite effects of diabetes on nephrotoxic and ischemic acute tubular necrosis.},
  author={H. Wald and Harold Markowitz and Shoshana Zevin and Mordecai M. Popovtzer},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1990},
  volume={195 1},
  pages={51-6}
}
The effect of streptozotocin-induced diabetes mellitus on two different models of acute tubular necrosis (ATN), was studied: (i) the nephrotoxic model of HgCl2-induced ATN and (ii) the ischemic model of renal artery clamping for 60 min. Induction of ATN with HgCl2 in normal rats decreased CrCl from 0.67 +/- 0.05 to 0.1 +/- 0.019 ml/min (P less than 0.001) after 24 hr, and it deteriorated further to 0.03 +/- 0.013 ml/min after 48 hr; whereas, in the diabetic rats, HgCl2 decreased CrCl from 0.98… CONTINUE READING