Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells


The slow inward Ca2+ current, ICa, is fundamental in the initiation of cardiac contraction and neurohormonal regulation of cardiac function1. It is increased by β-adrenergic agonists, which stimulate synthesis of cyclic AMP (cAMP) and cAMP-dependent phosphorylation2–4. The neurotransmitter acetylcholine reduces ICa5–7 by an unknown mechanism8,9. There is… (More)
DOI: 10.1038/323273a0


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