Opposite effects of cell growth factors and cicletanine sulfate on the sodium-independent [Cl-/HCO3-] exchange in cultured vascular smooth muscle.

@article{Fanous1993OppositeEO,
  title={Opposite effects of cell growth factors and cicletanine sulfate on the sodium-independent [Cl-/HCO3-] exchange in cultured vascular smooth muscle.},
  author={K. Fanous and C. Nazaret and N. Senn and E. Decoopman-Morin and M. Allard and R. Garay},
  journal={American journal of hypertension},
  year={1993},
  volume={6 8},
  pages={
          674-9
        }
}
  • K. Fanous, C. Nazaret, +3 authors R. Garay
  • Published 1993
  • Medicine
  • American journal of hypertension
  • Cicletanine sulfate was tested on bicarbonate-dependent pHi changes in cultured vascular smooth muscle (A10 line). Cicletanine sulfate exhibited double reactivity with regard to the cell alkalinization induced by bicarbonate uptake. The analysis of 11 concentration-response curves revealed a high reactivity component (IC50 approximately 3.5 x 10(-8) mol/L) and a weak reactivity component (IC50 approximately 4 x 10(-4) ml/L). Regarding the cell acidification induced by bicarbonate extrusion… CONTINUE READING
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