Opposite effects of angiotensin II and the protein kinase C activator OAG on cardiac Na+ channels

@article{Benz1992OppositeEO,
  title={Opposite effects of angiotensin II and the protein kinase C activator OAG on cardiac Na+ channels},
  author={Inga Benz and Joachim W. Herzig and M. Kohlhardt},
  journal={The Journal of Membrane Biology},
  year={1992},
  volume={130},
  pages={183-190}
}
Elementary Na+ currents were recorded at 19°C in cell-attached and inside-out patch-clamp experiments to study the influence of the vasoactive peptide angiotensin II (A II) and of the diacylglycerol analogue OAG (1-oleoyl-2-acetyl-snglycerol) on open probability and gating properties of single cardiac Na+ channels from cultured neonatal rat cardiocytes. Treating the cardiocytes with A II caused Na+ channel activation: reconstructed peak INa increased to 137 ± 17.5% of control at 3 μmol/liters… CONTINUE READING

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