Opposite effects of anandamide and n‐arachidonoyl dopamine in the regulation of prostaglandin E2 and 8‐iso‐PGF2α formation in primary glial cells

@article{Navarrete2009OppositeEO,
  title={Opposite effects of anandamide and n‐arachidonoyl dopamine in the regulation of prostaglandin E2 and 8‐iso‐PGF2α formation in primary glial cells},
  author={C. Navarrete and B. Fiebich and Amaya Garc{\'i}a de Vinuesa and S. Hess and A. C. P. de Oliveira and E. Candelario-Jalil and F. J. Caballero and M. Calzado and E. Mu{\~n}oz},
  journal={Journal of Neurochemistry},
  year={2009},
  volume={109}
}
It is widely accepted that neuroinflammation is a key player in various pathological events associated with brain injury. More specifically, glial activation and the subsequent release of pro‐inflammatory cytokines, reactive oxygen species (ROS), and prostaglandins play a role of paramount importance in cerebral damage. In this study, we examined the role of two endocannabinoids, anandamide (AEA) and N‐arachidonoyldopamine (NADA) in the regulation of prostaglandin E2 (PGE2) synthesis in primary… Expand
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