Opposite effects mediated by CCKA and CCKB receptors in behavioural and hormonal studies in rats

@article{Mnnist1994OppositeEM,
  title={Opposite effects mediated by CCKA and CCKB receptors in behavioural and hormonal studies in rats},
  author={Pekka T. M{\"a}nnist{\"o} and Aavo Lang and Jaanus Harro and Else Peuranen and Jacques Bradwejn and E. E. Vasar},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1994},
  volume={349},
  pages={478-484}
}
We compared the influence of two cholecystokinin (CCK) antagonists, devazepide and L,365,260 [3R-(+)-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1 H-1,4-benzodiazepine-3y1)-N′-(3-methyl-phenyl)urea], upon two distinct phenomena, behavioural and hormonal effects of caerulein (5 μg/kg s.c.), and unselective CCK agonist, in rats. Behavioural effects were assessed in the elevated plusmaze and open field tests. In separate experiments, effects on thyrotropin (TSH), prolactin (PRL) and growth hormone (GH… CONTINUE READING
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Cholecysto - kinin - A and cholecystokinin - B receptors in neurons of the brainstem solitary complex of the rat : pharmacological identification

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