Opposite effect of NF-kappa B and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite.

@article{Song2001OppositeEO,
  title={Opposite effect of NF-kappa B and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite.},
  author={Erwei Song and Yiling Lu and Zhenping Zhang and Val Vallyathan and Min Ding and Vincent Castranova and Xianglin Shi},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 14},
  pages={11414-9}
}
Cell cycle checkpoint, a major genomic surveillance mechanism, is an important step in maintaining genomic stability and integrity in response to environmental stresses. Using cells derived from human bronchial epithelial cells, we demonstrate that NF-kappaB and c-Jun N-terminal kinase (JNK) reciprocally regulate arsenic trioxide (arsenite)-induced, p53-independent expression of GADD45 protein, a cell cycle checkpoint protein that arrests cells at the G(2)/M phase transition. Inhibition of NF… CONTINUE READING

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