Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density

@inproceedings{Gross2016OppositeEO,
  title={Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density},
  author={Kellie S. Gross and Dieter D Brandner and Luis Andr{\'e}s Lara Mart{\'i}nez and M Foster Olive and Robert L. Meisel and Paul G Mermelstein},
  booktitle={PloS one},
  year={2016}
}
The group I metabotropic glutamate receptors (mGluR1a and mGluR5) are important modulators of neuronal structure and function. Although these receptors share common signaling pathways, they are capable of having distinct effects on cellular plasticity. We investigated the individual effects of mGluR1a or mGluR5 activation on dendritic spine density in medium spiny neurons in the nucleus accumbens (NAc), which has become relevant with the potential use of group I mGluR based therapeutics in the… CONTINUE READING
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