Opposing views on the alveolar surface, alveolar models, and the role of surfactant.

@article{Scarpelli2000OpposingVO,
  title={Opposing views on the alveolar surface, alveolar models, and the role of surfactant.},
  author={Emile M. Scarpelli and Brian Andrew Hills},
  journal={Journal of applied physiology},
  year={2000},
  volume={89 2},
  pages={
          408-12
        }
}
Emile M. Scarpelli: There is a body of work that relates directly and specifically to the review article of Dr. Hills, “An alternative view of the role(s) of surfactant and the alveolar model,” which appeared in the November 1999 issue of the Journal of Applied Physiology ([5][1]). In August 
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Alveolar histophysiology is researched with animal experiments that combined a conventional histological approach with in vivo microscopy to assess alveolar dynamics during normal and disease-state ventilation and indicates that the various behaviors reportedly exhibited by alveoli may be consistent and represent a continuum between normal alveolars function and thealveolar mechanics of acute lung injury.
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  • 2003
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Alveolar micromechanics and specifically the mechanical interactions between lung matrix and alveolar epithelial cell cytoskeleton and plasma membrane are considered and the lipid-trafficking responses of in vitro deformed and/or injured cells are detailed.
A two-dimensional hexagonal network model of alveolar mechanics
Pulmonary micromechanics (at the scale of alveoli) involves a delicate balance among tissue material properties, geometry, surface tension, pressure and stress distribution. To date, there is not a…
Microbubble dispersions of natural lung surfactant
The effect of elevated dietary cholesterol on pulmonary surfactant function in adolescent mice
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The results suggested that increased cholesterol in hc‐SAF induced less stability in the SAF possibly due to cholesterol's fluidizing effect on phospholipids at physiological temperatures.
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References

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An alternative view of the role(s) of surfactant and the alveolar model.
  • B. Hills
  • Biology
    Journal of applied physiology
  • 1999
TLDR
This review selectively reexamines each combination of alveolar model and role of surfactant for compatibility with the major features of pulmonary mechanics andAlveolar stability, morphology, and fluid balance.
Properties, Function and Origin of the Alveolar Lining Layer
TLDR
Equally stable foam is found in the bronchi of an animal the respiratory movements of which have been paralysed and into the trachea of which a mixture of oxygen and ammonia gas has been insufflated for one or two hours.
What is the true role of surfactant in the lung?
The surfactant identified' in the lung has been accorded two major roles. Firstly, it is believed that surfactant "reduces the work of expanding the lung with each breath" by reducing surface tension…
Arguments against and alternatives for an extracellular surfactant layer in the alveoli of mammalian lung.
Histological preservation and ultrastructure of alveolar surfactant.
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    Annual review of physiology
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TLDR
It is shown that tubular myelin, a liquid crystal, represents a large aggregate of surfactant lipids and proteins of still-unclear significance, andaborate fixation methods permit visualization in situ of localized pools of fluid that sometimes extend laterally, covering small areas of the alveolar surface.
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Intersegmental collateral ventilation in the human lung.
Pulmonary Physiology of the Fetus, Newborn and Child
TLDR
There are excellent and thought-provoking sections on the control of breathing and the complex forces operating between the alveoli, interstitial space, lymphatics, and the pulmonary capillaries.
The alveolar surface network: A new anatomy and its physiological significance
TLDR
The inherent structural and functional instability given TLUs by a broad liquid surface layer of this nature has been mitigated by the discovery that theTLU surface is in fact an agglomeration of bubbles, a foam that fills the TLU space and forms ultrathin foam films that impart infrastructural stability to sustain aeration.
Pulmonary physiology of the fetus, newborn, and child
TLDR
The main attraction of the book is as an account of how the specialty has evolved to a high degree of sophistication, and as such it makes a good read and can be commended.
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