Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

@article{Lu2014OpposingUS,
  title={Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis},
  author={Min Lu and David S Lawrence and Scot A. Marsters and Diego Acosta-Alvear and Philipp Kimmig and Aaron S. Mendez and Adrienne W Paton and James C Paton and Peter J. Walter and Avi Ashkenazi},
  journal={Science},
  year={2014},
  volume={345},
  pages={98-101}
}
Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption causes ER stress and augments disease. ER stress activates the unfolded protein response (UPR) to restore homeostasis. If stress persists, the UPR induces apoptotic cell death, but the mechanisms remain elusive. Here, we report that unmitigated ER stress promoted… CONTINUE READING