Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo.

@article{Verges2011OpposingSR,
  title={Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo.},
  author={Deborah K. Verges and Jessica L. Restivo and Whitney D Goebel and David M Holtzman and John R Cirrito},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 31},
  pages={11328-37}
}
The concentration of amyloid-β (Aβ) within the brain extracellular space is one determinant of whether the peptide will aggregate into toxic species that are important in Alzheimer's disease (AD) pathogenesis. Some types of synaptic activity can regulate Aβ levels. Here we demonstrate two distinct mechanisms that are simultaneously activated by NMDA receptors and regulate brain interstitial fluid (ISF) Aβ levels in opposite directions in the living mouse. Depending on the dose of NMDA… CONTINUE READING

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Low doses of NMDA increase action potentials and synaptic transmission which leads to an elevation in synaptic Aβ generation .
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