Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.

@article{Pepper2011OpposingSF,
  title={Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.},
  author={Marion Pepper and Antonio J. Pag{\'a}n and Botond Z. Igy{\'a}rt{\'o} and Justin J Taylor and Marc K Jenkins},
  journal={Immunity},
  year={2011},
  volume={35 4},
  pages={583-95}
}
Listeria monocytogenes infection generates T helper 1 (Th1) effector memory cells and CC chemokine receptor 7 (CCR7)(+) cells resembling central memory cells. We tracked endogenous L. monocytogenes-specific CD4(+) T cells to determine how these memory cells are formed. Two effector cell populations were already present several days after infection. One highly expressed the T-bet transcription factor and produced Th1 memory cells in an interleukin-2 (IL-2) receptor-dependent fashion. The other… CONTINUE READING
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