Opposing signals differentially regulate transcript stability in Aspergillus nidulans.

  title={Opposing signals differentially regulate transcript stability in Aspergillus nidulans.},
  author={Mark X. Caddick and Meriel G Jones and J Martin van Tonder and H{\'e}l{\`e}ne Le Cordier and Frank Narendja and Joseph Strauss and Igor Y Morozov},
  journal={Molecular microbiology},
  volume={62 2},
A good model for gene regulation, requiring the organism to monitor a complex and changing environment and respond in a precise and rapid way, is nitrogen metabolism in Aspergillus nidulans. This involves co-ordinated expression of hundreds of genes, many dependent on the transcription factor AreA, which monitors the nitrogen state of the cell. AreA activity is in part modulated by differential degradation of its transcript in response to intracellular glutamine. Here we report that glutamine… CONTINUE READING

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