Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.

@article{Jing2011OpposingRO,
  title={Opposing roles of NF-$\kappa$B in anti-cancer treatment outcome unveiled by cross-species investigations.},
  author={Hua Jing and J. Kase and J. D{\"o}rr and M. Milanovic and D. Lenze and M. Grau and Gregor Beuster and Sujuan Ji and M. Reimann and P. Lenz and M. Hummel and B. Dörken and G. Lenz and C. Scheidereit and C. Schmitt and Soyoung Lee},
  journal={Genes \& development},
  year={2011},
  volume={25 20},
  pages={
          2137-46
        }
}
In malignancies, enhanced nuclear factor-κB (NF-κB) activity is largely viewed as an oncogenic property that also confers resistance to chemotherapy. Recently, NF-κB has been postulated to participate in a senescence-associated and possibly senescence-reinforcing cytokine response, thereby suggesting a tumor-restraining role for NF-κB. Using a mouse lymphoma model and analyzing transcriptome and clinical data from lymphoma patients, we show here that therapy-induced senescence presents with and… Expand
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Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance.
The diverse and complex roles of NF-κB subunits in cancer
  • N. Perkins
  • Biology, Medicine
  • Nature Reviews Cancer
  • 2012
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References

SHOWING 1-10 OF 55 REFERENCES
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity.
Myc suppression of Nfkb2 accelerates lymphomagenesis
Oncogenic activation of NF-kappaB.
  • L. Staudt
  • Biology, Medicine
  • Cold Spring Harbor perspectives in biology
  • 2010
Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma
Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cells
...
1
2
3
4
5
...