Opposing roles of Akt and STAT3 in the protection of the maternal heart from peripartum stress.

@article{RickeHoch2014OpposingRO,
  title={Opposing roles of Akt and STAT3 in the protection of the maternal heart from peripartum stress.},
  author={Melanie Ricke-Hoch and Insa Bultmann and Britta Stapel and Gianluigi Condorelli and Ursula Rinas and Karen Sliwa and Michaela Scherr and Denise Hilfiker-Kleiner},
  journal={Cardiovascular research},
  year={2014},
  volume={101 4},
  pages={587-96}
}
BACKGROUND Peripartum cardiomyopathy (PPCM) is a pregnancy-associated cardiomyopathy in previously healthy women. Mice with a cardiomyocyte-restricted deletion of signal transducer and activator of transcription-3 (STAT3, CKO) develop PPCM. PI3K-Akt signalling is thought to promote cardiac hypertrophy and protection during pregnancy. We evaluated the role of activated Akt signalling in the maternal heart postpartum. METHODS AND RESULTS CKO mice were bred to mice harbouring an Akt transgene… CONTINUE READING
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