Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation.

@article{Corn2005OpposingRF,
  title={Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation.},
  author={Radiah A. Corn and Chris T Hunter and Hsiou-chi Liou and Ulrich K Siebenlist and Mark R. Boothby},
  journal={Journal of immunology},
  year={2005},
  volume={175 4},
  pages={2102-10}
}
CD4+ T cells with a block in the NF-kappaB signaling pathway exhibit decreases in Th1 responses and diminished nuclear levels of multiple transactivating NF-kappaB/Rel/IkappaB proteins. To determine the lineage-intrinsic contributions of these transactivators to Th differentiation, T cells from mice deficient in specific subunits were cultured in exogenous cytokines promoting either Th1 or Th2 differentiation. RelB-deficient cells exhibited dramatic defects in Th1 differentiation and IFN-gamma… CONTINUE READING

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