Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons.

@article{Ivanov2006OpposingRO,
  title={Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons.},
  author={Anton I. Ivanov and Christophe Pellegrino and Sylvain Rama and Iryna Dumalska and Yuriy Salyha and Yehezkel Ben-Ari and Igor Medina},
  journal={The Journal of physiology},
  year={2006},
  volume={572 Pt 3},
  pages={789-98}
}
The extracellular signal-regulated kinases (ERK) signalling cascade is a key pathway that mediates the NMDA receptor (NMDAR)-dependent neuronal plasticity and survival. However, it is not clear yet how NMDARs regulate ERK activity. Stimulation of the NMDARs induces a complex modification of ERK that includes both ERK activation and inactivation and depends on particular experimental conditions. Here we show that there exists a differential restriction in the regulation of ERK activity that… CONTINUE READING
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