Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages

Abstract

Tumor necrosis factor (TNF) is best known for inducing a rapid but transient NF-κB-mediated inflammatory response. We investigated later phases of TNF signaling, after the initial transient induction of inflammatory genes has subsided, in primary human macrophages. TNF signaling induced expression of late response genes, including inhibitors of NF-κB and… (More)
DOI: 10.1038/srep31959

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Cite this paper

@inproceedings{Huynh2016OpposingRO, title={Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages}, author={Linda Huynh and Anthony Kusnadi and Sung Ho Park and Koichi Murata and Kyung-Hyun Park-Min and Lionel B Ivashkiv}, booktitle={Scientific reports}, year={2016} }