Opposing neural effects of naltrexone on food reward and aversion: implications for the treatment of obesity

@article{Murray2014OpposingNE,
  title={Opposing neural effects of naltrexone on food reward and aversion: implications for the treatment of obesity},
  author={Elizabeth Murray and Sietske Brouwer and Rob McCutcheon and Catherine J. Harmer and Philip J. Cowen and Ciara McCabe},
  journal={Psychopharmacology},
  year={2014},
  volume={231},
  pages={4323-4335}
}
Opioid antagonism reduces the consumption of palatable foods in humans but the neural substrates implicated in these effects are less well understood. The aim of the present study was to examine the effects of the opioid antagonist, naltrexone, on neural response to rewarding and aversive sight and taste stimuli. We used functional magnetic resonance imaging (fMRI) to examine the neural responses to the sight and taste of pleasant (chocolate) and aversive (mouldy strawberry) stimuli in 20… CONTINUE READING