Opposing effects of low and high-dose clozapine on survival of transgenic amyotrophic lateral sclerosis mice.

@article{Turner2003OpposingEO,
  title={Opposing effects of low and high-dose clozapine on survival of transgenic amyotrophic lateral sclerosis mice.},
  author={Bradley J. Turner and Alan R Rembach and Richard Spark and Elizabeth C. Lopes and Surindar S. Cheema},
  journal={Journal of neuroscience research},
  year={2003},
  volume={74 4},
  pages={605-13}
}
Clozapine is a potent atypical neuroleptic or antipsychotic agent used to relieve symptoms of early-diagnosed schizophrenia. Aside from well-described dopamine and serotonin receptor blockade effects, clozapine may also be neuroprotective through its modulation of the p75 neurotrophin receptor (p75(NTR)) and superoxide dismutase 1 (SOD1) expression. The death-signalling activities of both p75(NTR) and mutant SOD1 are implicated in motor neuron degeneration in humans and transgenic mice with… CONTINUE READING
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