Opposing effects of estradiol- and testosterone-membrane binding sites on T47D breast cancer cell apoptosis.

@article{Kampa2005OpposingEO,
  title={Opposing effects of estradiol- and testosterone-membrane binding sites on T47D breast cancer cell apoptosis.},
  author={Marilena Kampa and Artemissia-Phoebe Nifli and Ioannis Charalampopoulos and Vassilia-Ismini Alexaki and Panayiotis Theodoropoulos and Efstathios Stathopoulos and Achilleas Gravanis and Elias Castanas},
  journal={Experimental cell research},
  year={2005},
  volume={307 1},
  pages={41-51}
}
Classical steroid mode of action involves binding to intracellular receptors, the later acting as ligand-activated nuclear transcription factors. Recently, membrane sites for different steroids have been also identified, mediating rapid, non-genomic, steroid actions. Membrane sites for estrogen and androgen have been found in a number of different cell types, bearing or not classical intracellular receptors. In the present study, with the use of radioligand binding, flow cytometry and confocal… CONTINUE READING

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