Opposing effects of dopaminergic to cholinergic compounds on a cerebral dopamine-activated adenylate cyclase.

@article{Tang1977OpposingEO,
  title={Opposing effects of dopaminergic to cholinergic compounds on a cerebral dopamine-activated adenylate cyclase.},
  author={L. C. Tang and George C. Cotzias},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1977},
  volume={74 2},
  pages={
          769-73
        }
}
  • L. Tang, G. C. Cotzias
  • Published 1 February 1977
  • Biology, Psychology
  • Proceedings of the National Academy of Sciences of the United States of America
In contrast to antipsychosis drugs which inhibit the dopamine-activated adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] of caudate nucleus, dopaminergic drugs for treatment of Parkinson's disease stimulate this cyclase. Stimulants and inhibitors of cholinergic neurons inhibited this adenylate cyclase activity competitively and specifically. Thus, the mechanism by which dopaminergic medications ameliorate the effects of Parkinson's disease includes activation of the dopamine… 
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