Opposing effects of anti-activation-inducible lymphocyte-immunomodulatory molecule/inducible costimulator antibody on the development of acute versus chronic graft-versus-host disease.

@article{Ogawa2001OpposingEO,
  title={Opposing effects of anti-activation-inducible lymphocyte-immunomodulatory molecule/inducible costimulator antibody on the development of acute versus chronic graft-versus-host disease.},
  author={Sachie K Ogawa and Gota Nagamatsu and Mika Watanabe and Satoshi Watanabe and Tamon Hayashi and Shigeru Horita and Kosaku Nitta and Hiroshi Nihei and Katsunari Tezuka and Ryo Abe},
  journal={Journal of immunology},
  year={2001},
  volume={167 10},
  pages={
          5741-8
        }
}
The functional role of inducible costimulator (ICOS)-mediated costimulation was examined in an in vivo model of alloantigen-driven Th1 or Th2 cytokine responses, the parent-into-F(1) model of acute or chronic graft-vs-host disease (GVHD), respectively. When the Ab specific for mouse ICOS was injected into chronic GVHD-induced mice, activation of B cells, production of autoantibody, and development of glomerulonephritis were strongly suppressed. In contrast, the same treatment enhanced donor T… CONTINUE READING
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